Prognostic value of diffusion-weighted MRI for post-cardiac arrest coma
Karen G Hirsch, Nancy Fischbein, Michael Mlynash, Stephanie Kemp, Roland Bammer, Irina Eyngorn, Julia Tong, Michael Moseley, Chitra Venkatasubramanian, Anna Finley Caulfield, Gregory Albers
Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
ObjectiveTo validate quantitative diffusion-weighted imaging (DWI) MRI thresholds that correlate with poor outcome in comatose cardiac arrest survivors, we conducted a clinician-blinded study and prospectively obtained MRIs from comatose patients after cardiac arrest.MethodsConsecutive comatose post-cardiac arrest adult patients were prospectively enrolled. MRIs obtained within 7 days after arrest were evaluated. The clinical team was blinded to the DWI MRI results and followed a prescribed prognostication algorithm. Apparent diffusion coefficient (ADC) values and thresholds differentiating good and poor outcome were analyzed. Poor outcome was defined as a Glasgow Outcome Scale score of ≤2 a..View full abstract
Awarded by NIH National Heart, Lung, and Blood Disorders Institute
Funded by the NIH National Heart, Lung, and Blood Disorders Institute (1R01HL089116-01A2).