Journal article

Prognostic value of diffusion-weighted MRI for post-cardiac arrest coma

Karen G Hirsch, Nancy Fischbein, Michael Mlynash, Stephanie Kemp, Roland Bammer, Irina Eyngorn, Julia Tong, Michael Moseley, Chitra Venkatasubramanian, Anna Finley Caulfield, Gregory Albers

Neurology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020


ObjectiveTo validate quantitative diffusion-weighted imaging (DWI) MRI thresholds that correlate with poor outcome in comatose cardiac arrest survivors, we conducted a clinician-blinded study and prospectively obtained MRIs from comatose patients after cardiac arrest.MethodsConsecutive comatose post-cardiac arrest adult patients were prospectively enrolled. MRIs obtained within 7 days after arrest were evaluated. The clinical team was blinded to the DWI MRI results and followed a prescribed prognostication algorithm. Apparent diffusion coefficient (ADC) values and thresholds differentiating good and poor outcome were analyzed. Poor outcome was defined as a Glasgow Outcome Scale score of ≤2 a..

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University of Melbourne Researchers