Journal article

Echocardiographic screening to determine progression of latent rheumatic heart disease in endemic areas: A systematic review and meta-analysis

Sarah J Gutman, Elad Shemesh, Thomas H Marwick, Andrew J Taylor



BACKGROUND: The World Health Organisation previously recommended routine screening in school-aged children in countries with a high prevalence of rheumatic heart disease (RHD); however, it is unclear if screening-detected (latent) valve disease will inevitably evolve to a pathological lesion. Understanding the natural history of latent RHD is essential prior to recommendation of screening in endemic areas. Studies documenting the progression of latent RHD have had contrasting conclusions about the pathogenicity of latent valvular lesions. This review provides estimates of rates of progression of latent RHD. METHODS AND FINDINGS: In this systematic review and meta-analysis, we searched EMBASE..

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Funding Acknowledgements

This project was supported by a grant from St. Vincent's Health Australia(SJG). SJG is supported by a dual funded National Health and Medical Research Council and National Heart Foundation Postgraduate Scholarship (Australia) and a Baker Brightsparks Top-up Scholarship. St. Vincent's Health: National Health and Medical Research Council: National Heart Foundation: Baker Heart and Diabetes Institute: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.