Journal article

Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions

Sophie C Payne, Glenn Ward, Richard J MacIsaac, Tomoko Hyakumura, James B Fallon, Joel Villalobos

Physiological Reports | WILEY | Published : 2020

Abstract

Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the effect various electrical vagus nerve stimulation strategies have on glycemia and glucose-regulating hormones, as a first step to developing a novel therapy of type 2 diabetes. Sprague-Dawley rats were anesthetized, the abdominal (anterior) vagus nerve implanted, and various stimulation strategies applied to the nerve: (a) 15 Hz; (b) 4 kHz, or 40 kHz and; (c) a combination of 15 Hz and 40 kHz to directionally activate afferent or efferent vagal fibers. Following a glucose bolus (500 mg/kg, I.V.), stimulation strategies wer..

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Grants

Awarded by St. Vincent's Research Endowment Fund


Awarded by Cass Foundation Limited


Awarded by University of Melbourne's Early Career Researcher Grants Scheme


Funding Acknowledgements

Research reported in this publication was supported by the St. Vincent's Research Endowment Fund (85257), the Cass Foundation Limited (8511), and the University of Melbourne's Early Career Researcher Grants Scheme (1757246). The Bionics Institute acknowledge the support they receive from the Victorian Government through its Operational Infrastructural Support Program.