Differential effects of vagus nerve stimulation strategies on glycemia and pancreatic secretions
Sophie C Payne, Glenn Ward, Richard J MacIsaac, Tomoko Hyakumura, James B Fallon, Joel Villalobos
Physiological Reports | WILEY | Published : 2020
Despite advancements in pharmacotherapies, glycemia is poorly controlled in type 2 diabetic patients. As the vagus nerve regulates energy metabolism, here we evaluated the effect various electrical vagus nerve stimulation strategies have on glycemia and glucose-regulating hormones, as a first step to developing a novel therapy of type 2 diabetes. Sprague-Dawley rats were anesthetized, the abdominal (anterior) vagus nerve implanted, and various stimulation strategies applied to the nerve: (a) 15 Hz; (b) 4 kHz, or 40 kHz and; (c) a combination of 15 Hz and 40 kHz to directionally activate afferent or efferent vagal fibers. Following a glucose bolus (500 mg/kg, I.V.), stimulation strategies wer..View full abstract
Awarded by St. Vincent's Research Endowment Fund
Awarded by Cass Foundation Limited
Awarded by University of Melbourne's Early Career Researcher Grants Scheme
Research reported in this publication was supported by the St. Vincent's Research Endowment Fund (85257), the Cass Foundation Limited (8511), and the University of Melbourne's Early Career Researcher Grants Scheme (1757246). The Bionics Institute acknowledge the support they receive from the Victorian Government through its Operational Infrastructural Support Program.