Tracing upconversion nanoparticle penetration in human skin.
Zahra Khabir, Anna E Guller, Vlada S Rozova, Liuen Liang, Yi-Jen Lai, Ewa M Goldys, Honghua Hu, Karen Vickery, Andrei V Zvyagin
Colloids and Surfaces B: Biointerfaces | Elsevier | Published : 2019
Due to their unique optical properties upconversion nanoparticles (UCNPs) provide exceptionally high contrast for imaging of true nanoparticle distribution in excised human skin. It makes possible to show penetration of solid nanoparticles in skin treated with chemical enhancers. We demonstrated tracing upconversion nanoparticles in excised human skin by means of optical microscopy at the discrete particle level sensitivity to obtain their penetration profiles, which was validated by laser-ablation inductively-coupled-plasma mass-spectrometry. To demonstrate utilities of our method, UCNPs were coated with polymers, formulated in water and chemical enhancers, and applied on excised human skin..View full abstract