Journal article

Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy

Mengbo Li, Benjamin L Parker, Evangeline Pearson, Benjamin Hunter, Jacob Cao, Yen Chin Koay, Oneka Guneratne, David E James, Jean Yang, Sean Lal, John F O'Sullivan



Poor access to human left ventricular myocardium is a significant limitation in the study of heart failure (HF). Here, we utilise a carefully procured large human heart biobank of cryopreserved left ventricular myocardium to obtain direct molecular insights into ischaemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM), the most common causes of HF worldwide. We perform unbiased, deep proteomic and metabolomic analyses of 51 left ventricular (LV) samples from 44 cryopreserved human ICM and DCM hearts, compared to age-, gender-, and BMI-matched, histopathologically normal, donor controls. We report a dramatic reduction in serum amyloid A1 protein in ICM hearts, perturbed thyroid hormone..

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University of Melbourne Researchers


Funding Acknowledgements

We thank the patients and staff of St Vincent's Hospital, Sydney, and the Australian Red Cross Blood Service. We thank Emeritus Prof. Cris dos Remedios and the Late Dr. Victor Chang AC. We thank Ben Crossett and Stuart Cordwell from Sydney Mass Spectrometry. This was supported by the National Health and Medical Research Council (NHMRC) of Australia. The contents of the published material are solely the responsibility of the individual authors and do not reflect the view of NHMRC.