Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors
Susan Ellul, Wolfgang Marx, Fiona Collier, Richard Saffery, Mimi Tang, David Burgner, John Carlin, Peter Vuillermin, Anne-Louise Ponsonby, Len Harrison, Terry Dwyer, Sarath Ranganathan, Peter Sly
Prostaglandins, Leukotrienes and Essential Fatty Acids | ELSEVIER SCI LTD | Published : 2020
BACKGROUND: Fatty acids have been implicated in early life immune development. Food allergy provides a clear phenotype of early allergic disease. Fish oil and vitamin D have immune-modulating properties. We aimed to identify the metabolomic profile of (i) infant food allergy and (ii) factors linked to food allergy in past studies such as fish oil supplementation and serum 25OHD3 levels in early life. METHODS: NMR was used to quantify 73 metabolites in plasma of 1 year old infants from the Barwon Infant Study (n=485). Logistic regression models were used to examine associations between infant metabolome and food allergy in infants. Linear regression models were used to describe associations b..View full abstract
Awarded by NHMRC Senior Research Fellowships
We thank the BIS participants for the generous contribution they have made to this project. We also thank current and past staff for their efforts in recruiting and maintaining the cohort and in obtaining and processing the data and biospecimens. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia (NHMRC), The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Limited and the Percy Baxter Charitable Trust, Perpetual Trustees. In-kind support was provided by the Cotton On Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. This work was also supported by NHMRC Senior Research Fellowships (APP1008396 to ALP; APP1064629 to DB; APP1045161 to RS).