Journal article
Replication of a hippocampus specific effect of the tescalcin regulating variant rs7294919 on gray matter structure
J Goltermann, N Opel, R Redlich, J Repple, C Kaehler, D Grotegerd, K Dohm, EJ Leehr, J Böhnlein, K Förster, S Meinert, V Enneking, D Emden, R Leenings, NR Winter, T Hahn, S Mikhail, A Jansen, A Krug, I Nenadić Show all
European Neuropsychopharmacology | ELSEVIER | Published : 2020
Abstract
While the hippocampus remains a region of high interest for neuropsychiatric research, the precise contributors to hippocampal morphometry are still not well understood. We and others previously reported a hippocampus specific effect of a tescalcin gene (TESC) regulating single nucleotide polymorphism (rs7294919) on gray matter volume. Here we aimed to replicate and extend these findings. Two complementary morphometric approaches (voxel based morphometry (VBM) and automated volumetric segmentation) were applied in a well-powered cohort from the Marburg-Münster Affective Disorder Cohort Study (MACS) including N=1137 participants (n=636 healthy controls, n=501 depressed patients). rs7294919 ho..
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Awarded by Janssen Pharmaceuticals
Funding Acknowledgements
This work is part of the German multicenter consortium "Neurobiology of Affective Disorders. A translational perspective on brain structure and function", funded by the German Research Foundation (Deutsche Forschungsgemeinschaft DFG; Forschungsgruppe/Research Unit FOR2107). DFG grant numbers KI 588/14-1, KI 588/14-2, DA 1151/5-1, DA 1151/5-2, KR 3822/5-1, KR 3822/7-2, NE 2254/1-2, KO 4291/3-1, RI 908/11-1, RI 908/11-2, NO 246/10-1, NO 246/10-2, WI 3439/3-1, WI 3439/3-2, JA 1890/7-1, JA 1890/7-2, HA 7070/2-2, MU1315/8-2, DE 1614/3-1, DE 1614/3-2, PF 784/1-1, PF 784/1-2, RE 737/20-1, RE 737/20-2, KI 588/15-1, KI 588/17-1, DA 1151/6-1, KO 4291/4-1. Author NO was supported by the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster (grant SEED 11/18 to NO).