Journal article
Brain functional effects of electroconvulsive therapy during emotional processing in major depressive disorder
V Enneking, F Dzvonyar, K Dück, K Dohm, D Grotegerd, K Förster, S Meinert, H Lemke, M Klug, L Waltemate, J Goltermann, C Hülsmann, T Borgers, J Böhnlein, L Sindermann, M Richter, EJ Leehr, J Repple, N Opel, BT Baune Show all
Brain Stimulation | ELSEVIER SCIENCE INC | Published : 2020
Abstract
Background: In treatment-resistant major depressive disorder (MDD), electroconvulsive therapy (ECT) is a treatment with high efficacy. While knowledge regarding changes in brain structure following ECT is growing, the effects of ECT on brain function during emotional processing are largely unknown. Objective: We investigated the effects of ECT on the activity of the anterior cingulate cortex (ACC) and amygdala during negative emotional stimuli processing and its association with clinical response. Methods: In this non-randomized longitudinal study, patients with MDD (n = 37) were assessed before and after treatment with ECT. Healthy controls (n = 37) were matched regarding age and gender. Fu..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
This work was supported by grants of the Innovative Medizinische Forschung, Munster, Germany [RE111604 and RE111722 to RR], and the German Research Foundation [DFG, grant RE4458/1-1 to RR, FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD] and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [grant Dan3/012/17 to UD]. These affiliations are of no relevance to the work described in the manuscript.