Brain functional effects of electroconvulsive therapy during emotional processing in major depressive disorder
Verena Enneking, Fanni Dzvonyar, Kerstin Dueck, Katharina Dohm, Dominik Grotegerd, Katharina Foerster, Susanne Meinert, Hannah Lemke, Melissa Klug, Lena Waltemate, Janik Goltermann, Carina Huelsmann, Tiana Borgers, Joscha Boehnlein, Lisa Sindermann, Maike Richter, Elisabeth J Leehr, Jonathan Repple, Nils Opel, Bernhard T Baune Show all
Brain Stimulation | ELSEVIER SCIENCE INC | Published : 2020
BACKGROUND: In treatment-resistant major depressive disorder (MDD), electroconvulsive therapy (ECT) is a treatment with high efficacy. While knowledge regarding changes in brain structure following ECT is growing, the effects of ECT on brain function during emotional processing are largely unknown. OBJECTIVE: We investigated the effects of ECT on the activity of the anterior cingulate cortex (ACC) and amygdala during negative emotional stimuli processing and its association with clinical response. METHODS: In this non-randomized longitudinal study, patients with MDD (n = 37) were assessed before and after treatment with ECT. Healthy controls (n = 37) were matched regarding age and gender. Fu..View full abstract
Awarded by Innovative Medizinische Forschung, Munster, Germany
Awarded by German Research Foundation [DFG]
Awarded by Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster
This work was supported by grants of the Innovative Medizinische Forschung, Munster, Germany [RE111604 and RE111722 to RR], and the German Research Foundation [DFG, grant RE4458/1-1 to RR, FOR2107 DA1151/5-1 and DA1151/5-2 to UD; SFB-TRR58, Projects C09 and Z02 to UD] and the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Munster [grant Dan3/012/17 to UD]. These affiliations are of no relevance to the work described in the manuscript.