Journal article

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex

Yi-Lynn Liang, Maryam Khoshouei, Alisa Glukhova, Sebastian GB Furness, Peishen Zhao, Lachlan Clydesdale, Cassandra Koole, Tin T Truong, David M Thal, Saifei Lei, Mazdak Radjainia, Radostin Danev, Wolfgang Baumeister, Ming-Wei Wang, Laurence J Miller, Arthur Christopoulos, Patrick M Sexton, Denise Wootten

Nature | NATURE PUBLISHING GROUP | Published : 2018

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by NHMRC


Awarded by Strategic Priority Research Program of the Chinese Academy of Sciences


Awarded by Shanghai Science and Technology Development Fund


Funding Acknowledgements

The work was supported by the Monash University Ramaciotti Centre for Cryo-Electron Microscopy, the National Health and Medical Research Council of Australia (NHMRC) project grants (1061044, 1065410, 1120919 and 1126857), NHMRC program grant (1055134), Strategic Priority Research Program of the Chinese Academy of Sciences (XDA12020347) and Shanghai Science and Technology Development Fund (15DZ2291600). P.M.S., A.C., D.W. and C.K. are NHMRC Principal Research, Senior Principal Research, Career Development and CJ Martin Fellows, respectively. S.L. received the Postgraduate Overseas Study Fellowship from CAS. We thank J. Plitzko, G. Christopoulos, V. Julita, J. Michaelis, X. Zhang, P. Thompson and M. Liu for assay and technical support and B. Kobilka for technical advice and comments on the manuscript.