Journal article

Architecture of the Nitric-oxide Synthase Holoenzyme Reveals Large Conformational Changes and a Calmodulin-driven Release of the FMN Domain

Adam L Yokom, Yoshihiro Morishima, Miranda Lau, Min Su, Alisa Glukhova, Yoichi Osawa, Daniel R Southworth

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2014

DOI: 10.1074/jbc.M114.564005

Grants

Awarded by National Institutes of Health

Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Funding Acknowledgements

This work was supported by an American Heart Association Scientist Development Grant, National Institutes of Health Grant GM077430 (to Y. O.), and the University of Michigan Protein Folding Diseases Initiative.

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Keywords

Protein Binding
Activation
Life Sciences & Biomedicine
Heme Reduction
Electron Microscopy (em)
Electron-Transfer
Catalysis
Holoenzymes
Visualization
Amino Acid Sequence
Molecular Sequence Data
Cryo-Em Structure
Reductase Domain
Flavoproteins
Nitric-Oxide Synthase
Catalytic Domain
Oxygenase
Rats
Animals
Science & Technology
Microscopy
Calmodulin
Biochemistry & Molecular Biology
Oxidation-Reduction
Nitric Oxide Synthase Type I
No Complex-Formation