Journal article

The association between a fracture risk tool and frailty: Geelong Osteoporosis Study

Monica C Tembo, Kara L Holloway-Kew, Mohammadreza Mohebbi, Sophia X Sui, Sarah M Hosking, Sharon L Brennan-Olsen, Lana J Williams, Mark A Kotowicz, Julie A Pasco

BMC GERIATRICS | BMC | Published : 2020

Abstract

BACKGROUND: Frailty is characterised by age-related declines in physical, psychological and social functioning. Features of frailty overlap with risk factors for fragility fractures. The aim of this study was to investigate the association between the fracture risk assessment tool (FRAX®) and frailty. METHODS: In cross-sectional analysis, frailty status was determined for participants aged 60-90 yr at 15-year follow-up of the Geelong Osteoporosis Study, using a modified Fried frailty phenotype. Using the FRAX on-line tool, scores for hip and major osteoporotic fracture (MOF) were calculated with and without bone mineral density (BMD). Using the area under Receiver Operating Characteristic (A..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Australia


Awarded by NHMRC Career Development Fellowship


Awarded by NHMRC Investigator grant


Funding Acknowledgements

The Geelong Osteoporosis Study (GOS) was funded by the National Health and Medical Research Council (NHMRC) Australia (projects 299831, 251638, 628582). The funding organisation played no role in the design or conduct of the study, in the collection, management, analysis and interpretation of the data, nor in the preparation, review and approval of the manuscript. MCT and SXS were supported by Deakin Postgraduate Scholarships, KLH-K was supported by Alfred Deakin Postdoctoral Research Fellowship, LJW is supported by NHMRC Career Development Fellowship (1064272) and a NHMRC Investigator grant (1174060), SB-O was supported by NHMRC Career Development Fellowship (1107510) and SMH by a Faculty of Health Research Fellowship from Deakin University.