Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria
Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow
Current Opinion in Microbiology | CURRENT BIOLOGY LTD | Published : 2020
Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells. These effectors engage and manipulate host cellular functions to support bacterial colonization and propagation. The secretion systems are molecular machines that recognize targeting 'features' in these effector proteins in vivo to selectively and efficiently secrete them. The joint analysis of whole genome sequencing data and computational predictions of amino acid characteristics of effector proteins has made available extensive lists of candidate effectors for many bacterial pathogens, among which Dot/Icm type IVB secretion system in Legionella pneumophila rei..View full abstract
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Awarded by Australian Research Council
Awarded by National Health & Medical Research Council
YL is partially supported by the School of Biomedical Sciences and a Melbourne Research Scholarship, University of Melbourne, JW was supported by a Monash Research Scholarship. Research in HJNs laboratory is currently funded through an Australian Research Council Discover Project (DP180101298), research in TLs laboratory is currently funded through a National Health & Medical Research Council Program Grant (1092262).