Journal article

Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria

Yi Wei Lee, Jiawei Wang, Hayley J Newton, Trevor Lithgow

Current Opinion in Microbiology | CURRENT BIOLOGY LTD | Published : 2020

Abstract

Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells. These effectors engage and manipulate host cellular functions to support bacterial colonization and propagation. The secretion systems are molecular machines that recognize targeting 'features' in these effector proteins in vivo to selectively and efficiently secrete them. The joint analysis of whole genome sequencing data and computational predictions of amino acid characteristics of effector proteins has made available extensive lists of candidate effectors for many bacterial pathogens, among which Dot/Icm type IVB secretion system in Legionella pneumophila rei..

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University of Melbourne Researchers

Grants

Awarded by Australian Research Council


Awarded by National Health & Medical Research Council


Funding Acknowledgements

YL is partially supported by the School of Biomedical Sciences and a Melbourne Research Scholarship, University of Melbourne, JW was supported by a Monash Research Scholarship. Research in HJNs laboratory is currently funded through an Australian Research Council Discover Project (DP180101298), research in TLs laboratory is currently funded through a National Health & Medical Research Council Program Grant (1092262).