Journal article

Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Nicola J Armstrong, Karen A Mather, Muralidharan Sargurupremraj, Maria J Knol, Rainer Malik, Claudia L Satizabal, Lisa R Yanek, Wei Wen, Vilmundur G Gudnason, Nicole D Dueker, Lloyd T Elliott, Edith Hofer, Joshua Bis, Neda Jahanshad, Shuo Li, Mark A Logue, Michelle Luciano, Markus Scholz, Albert V Smith, Stella Trompet Show all

Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020

Abstract

BACKGROUND AND PURPOSE: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. METHODS: Participants were aged 45 years and older, free of stroke and dementia. We conducted genome-wide association analyses of PVWMH and DWMH in 26,654 participants from CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), ENIGMA (Enhancing Neuro-Imaging Genetics Through Meta-Analysis), and the UKB (UK Biobank). Regional correlations ..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Neurological Disorders and Stroke, National Institutes of Health


Awarded by Deutsche Forschungsgesellschaft (DFG)


Awarded by Free State of Saxony within LIFE-Leipzig Research Center for Civilization Diseases


Awarded by National Institute on Aging, Bethesda, MD


Funding Acknowledgements

This work is supported by the National Institute of Neurological Disorders and Stroke, National Institutes of Health, R01AG059874, P41EB015922, R56AG058854, U54 EB020403, R01AG022381, U54EB020403, R01AG059874, and R01NS115845. Medical Research Council, Age UK, Scottish Funding Council, Row Fogo Trust, The Welcome Trust, Age UK, Cross Council Lifelong Health and Wellbeing Initiative, Leverhulme Trust, National Institute for Health Research, Biotechnology and Biological Sciences Research Council, UK Medical Research Council, Icelandic Heart Association, and the Althingi, Austrian Science Fund (FWF), Australian National Health and Medical Research Council, Austrian National Bank, Anniversary Fund, European Commission FP6 STRP, European Community's 5th and 7th Framework Program, Netherlands Organization for Scientific Research, Netherlands Consortium for Healthy Aging, Russian Foundation for Basic Research, Russian Federal Agency of Scientific Organizations, Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and Technology, Norwegian National Advisory Unit for functional magnetic resonance imaging (MRI), Leipzig Research Center for Civilization Diseases (LIFE), Bristol-Myers Squibb, Netherlands Heart Foundation, French National Research Agency (ANR), Foundation Leducq, Joint Programme of Neurodegenerative Disease research, Bordeaux University, Institut Pasteur de Lille, the labex DISTALZ and the Centre National de Genotypage. Deutsche Forschungsgesellschaft (DFG) no. WI 3342/3-1 and grants from European Union, European Regional Development Fund, Free State of Saxony within the framework of the excellence initiative, LIFE-Leipzig Research Center for Civilization Diseases no. 100329290, 713-241202, 14505/2470, 14575/2470. Max Planck Society, State of Saxony, Brain Foundation, Bristol-Myers Squibb, National Health and Medical Research Council (NHMRC) of Australia, NHMRC of Australia, Parkinson's UK; Medical Research Council -Dementias Platform UK, National Institute on Aging, Bethesda, MD, P30 AG 010129 Full details of funding support for each cohort are detailed in the Data Supplement.