Journal article

Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: A birth cohort study

Anne-Louise Ponsonby, Christos Symeonides, Richard Saffery, Jochen F Mueller, Martin O'Hely, Peter D Sly, Nicole Wardrop, Angela Pezic, Toby Mansell, Fiona Collier, David Burgner, Kristie Thompson, Soumini Vijayasarathy, Eva J Sugeng, Terence Dwyer, Sarath Ranganathan, Peter J Anderson, Vicki Anderson, Peter Vuillermin



Prenatal phthalate chemicals may have adverse effects on brain development by various mechanisms including oxidant damage. However, birth cohort findings have been conflicting. This study aimed to (i) investigate the interplay between maternal prenatal phthalate levels, infant genetic vulnerability to oxidative stress, and child neurodevelopment and (ii) examine combined putative oxidant exposures. In a population-based birth cohort of 1064 women with prenatal recruitment in Victoria, Australia, maternal urine was collected at 36 weeks of pregnancy and phthalate metabolite concentrations measured. An unweighted genetic score for oxidative stress was made using a candidate gene approach. Cogn..

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Funding Acknowledgements

We thank the BIS participants for the generous contribution they have made to this project. We also thank current and past staff for their efforts in recruiting and maintaining the cohort and in obtaining and processing the data and biospecimens. The establishment work and infrastructure for the BIS was provided by the Murdoch Children's Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Shepherd Foundation, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation, GMHBA Ltd, The Gandel Foundation, The Percy Baxter Charitable Trust, Perpetual Trustees and the Gwenyth Raymond Trust. Vanguard Investments Australia Ltd provided funding for analysis of plasticisers in biospecimens. In-kind support was provided by the Cotton on Foundation and CreativeForce. Research at Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. A-L. Ponsonby, P. Vuillermin, D. Burgner, V. Anderson and P. Sly receive NHMRC fellowship support. C. Symeonides was supported by a NHMRC PhD scholarship. The BIS Investigator Group includes John Carlin, Mimi Tang and Len Harrison.