Journal article

Early intervention exercise training does not delay prostate cancer progression in Pten(-/-) mice

Renea A Taylor, Simon G Farrelly, Ashlee K Clark, Matthew J Watt

The Prostate | WILEY | Published : 2020

Abstract

BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of exercise therapy, although there is limited preclinical, and no clinical, data to directly support the notion that exercise training improves prostate cancer prognosis or outcome. The aim of this study was to investigate the effect of regular exercise training on the early stages of prostate cancer progression, as well as assessing whether alterations to prostate cancer metabolism are induced by exercise. METHODS: Mice with prostate-specific deletion of Pten (Pten-/- ) remained sedentary or underwent 6 weeks of endurance exercise training or high-intensity exerci..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Cancer Council Victoria


Awarded by Prostate Cancer Foundation of Australia


Awarded by Victorian Cancer Agency


Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: APP1077703; Cancer Council Victoria, Grant/Award Number: APP1160217; Prostate Cancer Foundation of Australia, Grant/Award Number: NCG 3313; Victorian Cancer Agency, Grant/Award Number: MCRF15023