Relationships between body mass index with oral estradiol dose and serum estradiol concentration in transgender adults undergoing feminising hormone therapy
Brendan J Nolan, Adam Brownhill, Ingrid Bretherton, Peggy Wong, Susan Fox, Peter Locke, Nicholas Russell, Mathis Grossmann, Jeffrey D Zajac, Ada S Cheung
Therapeutic Advances in Endocrinology and Metabolism | SAGE PUBLICATIONS LTD | Published : 2020
Aim: Feminising hormone therapy with estradiol is used to align an individual's physical characteristics with their gender identity. Given considerable variations in doses of estradiol therapy administered as gender-affirming hormone therapy (GAHT), we aimed to assess if body mass index (BMI) correlated with estradiol dose/concentration and assess the correlation between estradiol dose and estradiol concentrations. Methods: In a retrospective cross-sectional study, we analysed transgender individuals attending a primary or secondary care clinic in Melbourne, Australia who were prescribed oral estradiol valerate for at least 6 months and had estradiol dose and concentration available. Estradi..View full abstract
Awarded by Australian Government National Health and Medical Research Council Early Career Fellowship
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Brendan Nolan is supported by the Royal Australasian College of Physicians Fellows Research Entry Scholarship. Ada Cheung is supported by an Australian Government National Health and Medical Research Council Early Career Fellowship (#1143333) and receives research support from the Viertel Charitable Foundation Clinical Investigator Award, Endocrine Society of Australia Postdoctoral Award and the Royal Australasian College of Physicians.