Conference Proceedings
Nivolumab with neoadjuvant chemotherapy and adjuvant endocrine therapy in ER /HER2-primary breast cancer: CheckMate 7FL
Sherene Loi, Heather McArthur, Nadia Harbeck, Lajos Pusztai, Suzette Delaloge, Kristen Letrent, Tian Chen, Bin Li, Kay Tatsuoka, Dimitrios Zardavas, Giuseppe Curigliano
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2020
Abstract
Abstract Background: Estrogen receptor-positive (ER+), human epidermal growth factor receptor 2-negative (HER2−) primary breast cancer (BC) includes a group of heterogeneous tumors, spanning from biologically indolent, ER signaling-driven to aggressive, endocrine-resistant tumors. Patients (pts) diagnosed with ER+, HER2− BC of high grade and/or low ER expression are at increased risk of relapse, despite current standard of care (SoC): chemotherapy and endocrine treatment (ET) in the neo- and adjuvant settings, respectively. New treatment options to increase cure rates are needed. Increased understanding of ER+, HER2− BC immune biology show an enrichment of cases with tumor cel..
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