Higher levels of alpha 7 nicotinic receptors, but not choline acetyltransferase, in the dorsolateral prefrontal cortex from a sub-group of patients with schizophrenia
Brian Dean, Geoffrey Pavey, Elizabeth Scarr
Schizophrenia Research | ELSEVIER | Published : 2020
It has been suggested the study of sub-groups within the syndrome of schizophrenia will assist in elucidating the complex pathophysiology of the syndrome. Hence, we have studied a number of cholinergic markers in the cortex from a sub-group of subjects with schizophrenia that have a marked decrease in levels of muscarinic M1 receptors (MRDS). The displacement of [3H]NMS by cortical extracts was used to measure tissue anticholinergic load, [125I]α bungarotoxin binding was used to measure levels of the α7 nicotinic receptor (CHRNA7) and western blotting was used to measure levels of choline acetyltransferase (ChAT) 68 and 82 as well as synaptosome nerve-associated protein 25 (SNAP25). In compa..View full abstract
Awarded by NHMRC
The authors thank Madhara Udawela and Clare Duncan for the technical assistance that contributed to the data included in this manuscript. This research was funded in part by NHMRC Project Grant #APP1105332 and the CRC for Mental Health.