Molecular regulators of lipid metabolism in the intestine - Underestimated therapeutic targets for obesity?
Mercedes Davalos-Salas, John M Mariadason, Matthew J Watt, Magdalene K Montgomery
BIOCHEMICAL PHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2020
The incidence of obesity and type 2 diabetes continues to rise across the globe necessitating the need to identify new therapeutic approaches to manage these diseases. In this review, we explore the potential for therapeutic interventions focussed on the intestinal epithelium, by targeting the role of this tissue in lipid uptake, lipid-mediated cross talk and lipid oxidation. We focus initially on ongoing strategies to manage obesity by targeting the essential role of the intestinal epithelium in lipid uptake, and in mediating tissue cross talk to regulate food intake. Subsequently, we explore a previously underestimated capacity of intestinal epithelial cells to oxidize fatty acids. In this..View full abstract
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Awarded by NHMRC
MJW and MKM are supported by Research Fellowships from the NHMRC (APP1077703, APP1143224).