Prebötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

C Menuet; AA Connelly; JK Bassi; MR Melo; S Le; J Kamar; NN Kumar; SJ McDougall; S McMullan; AM Allen

Journal article

Prebötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

C Menuet, AA Connelly, JK Bassi, MR Melo, S Le, J Kamar, NN Kumar, SJ McDougall, S McMullan, AM Allen

Elife | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2020

DOI: 10.7554/eLife.57288

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Abstract

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated centrally, with respiratory neurons entraining the activity of pre-sympathetic and parasympathetic cardiovascular neurons. Using a combination of optogenetic inhibition and excitation in vivo and in situ in rats, as well as neuronal tracing, we demonstrate that preBötzinger Complex (preBötC) neurons, which form the kernel for inspiratory rhythm generation, directly modulate cardiovascular activity. Specifically, inhibitory preBötC neurons modulate cardiac parasympathetic neuron activity whilst excitatory preBötC neurons modulate sympathetic vasomotor neuron activity, gen..

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University of Melbourne Researchers

Angela Connelly Author

Jaspreet Bassi Author

Mariana Del Rosso De Melo Author

Stuart McDougall Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

[ "National Health and Medical Research Council App #1120477 Clement Menuet Simon McMullan Andrew M Allen", "National Health and Medical Research Council App #1156727 Clement Menuet Simon McMullan Andrew M Allen", "Australian Research Council DP120100920 Simon McMullan Andrew M Allen", "Australian Research Council DP170104582 Andrew M Allen", "University of Melbourne - McKenzie Research Fellowship Clement Menuet", "Fondation pour la Recherche Medicale Fellowship ARF20160936221 Clement Menuet", "The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication." ]