Leisure-Time Physical Activity Versus Sedentary Behaviour in Relation to Colorectal Adenoma and Cancer: Are these Two Distinct Risk Factors?

Abstract

Purpose of Review: This literature review provides an up-to-date overview of the evidence relating to the associations of leisure-time physical activity and sedentary behaviour with the risk of colorectal adenoma and cancer. A summary of possible biological mechanisms underpinning these associations is also presented. Recent Findings: Leisure-time physical activity and sedentary behaviour are often conceptualised as independent risk factors for colorectal adenoma and cancer. Regular leisure-time physical activity is associated with a 20%–25% reduction in colorectal cancer risk and an estimated 16% reduction in colonic adenoma. The risk estimates are similar for males and females, and for pro..