Serum cytokine concentrations and asthma persistence to middle age
Jingwen Zhang, Eugene H Walters, Mimi LK Tang, Adrian J Lowe, Caroline J Lodge, Dinh Bui, Rangi Kandane-Rathnayake, Bircan Erbas, Garun S Hamilton, Bruce R Thompson, Michael J Abramson, Graham G Giles, Jennifer L Perret, Shyamali C Dharmage
ALLERGY | WILEY | Published : 2020
Cytokines play a key role as mediators in the immuno-pathogenesis of asthma.1 Age at asthma onset and the presence of T-helper 2 mediated eosinophilic airway inflammation have been identified as two important and distinct factors for defining asthma phenotypes,2 but little is known about longitudinal associations between systemic cytokine concentrations and asthma. In a previous investigation of serum cytokine concentrations among 44-year-old adults and asthma phenotypes, we found early-onset persistent asthma (from age 13 to 44 years) was associated with lower levels of interleukin (IL) -10, while asthma remission was associated with lower levels of IL-6 and TNF-α.3 We hypothesised that, in..View full abstract
JZ is supported by the China Scholarship Council-University of Melbourne PhD Scholarship. SCD. JLP, AJL, and EHW are supported by the National Health and Medical Research Council (NHMRC) of Australia. The Tasmanian Longitudinal Health Study was conducted with funding from NHMRC of Australia; The University of Melbourne; Clifford Craig Medical Research Trust of Tasmania; The Victorian, Queensland & Tasmanian Asthma Foundations; The Royal Hobart Hospital; Helen MacPherson Smith Trust; and GlaxoSmithKline.