Journal article

Repositioning of the global epicentre of non-optimal cholesterol

Cristina Taddei, Bin Zhou, Honor Bixby, Rodrigo M Carrillo-Larco, Goodarz Danaei, Rod T Jackson, Farshad Farzadfar, Marisa K Sophiea, Mariachiara Di Cesare, Maria Laura Caminia Iurilli, Andrea Rodriguez Martinez, Golaleh Asghari, Klodian Dhana, Pablo Gulayin, Sujay Kakarmath, Marilina Santero, Trudy Voortman, Leanne M Riley, Melanie J Cowan, Stefan Savin Show all

Nature | NATURE PUBLISHING GROUP | Published : 2020


High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to esti..

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Awarded by Wellcome Trust

Awarded by British Heart Foundation (Centre of Research Excellence)

Awarded by Wellcome Trust Research Training Fellowship

Funding Acknowledgements

This study was funded by a Wellcome Trust (Biomedical Resource & Multi-User Equipment grant 01506/Z/13/Z) and the British Heart Foundation (Centre of Research Excellence grant RE/18/4/34215). C.T. was supported by a Wellcome Trust Research Training Fellowship (203616/Z/16/Z). The authors alone are responsible for the views expressed in this Article and they do not necessarily represent the views, decisions, or policies of the institutions with which they are affiliated.