Journal article

Pineal Gland Volume in Major Depressive and Bipolar Disorders

Tsutomu Takahashi, Daiki Sasabayashi, Murat Yucel, Sarah Whittle, Valentina Lorenzetti, Mark Walterfang, Michio Suzuki, Christos Pantelis, Gin S Malhi, Nicholas B Allen

Frontiers in Psychiatry | FRONTIERS MEDIA SA | Published : 2020

Abstract

Abnormal melatonin secretion has been demonstrated in patients with affective disorders such as major depressive disorder (MDD) and bipolar disorder (BD). However, magnetic resonance imaging (MRI) studies that previously investigated the volume of the pineal gland, which regulates circadian rhythms by secreting melatonin, in these patients reported inconsistent findings. The present study employed MRI to examine pineal gland volumes and pineal cyst prevalence in 56 MDD patients (29 currently depressed and 27 remitted patients), 26 BD patients, and matched controls (33 for MDD and 24 for BD). Pineal volumes and cyst prevalence in the current MDD, remitted MDD, and BD groups did not significan..

View full abstract

Grants

Awarded by JSPS KAKENHI


Awarded by Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from the Japan Agency for Medical Research and Development (AMED)


Funding Acknowledgements

This work was supported in part by JSPS KAKENHI Grant Number No. JP18K07550 to TT, JP18K15509 to DS, and by Health and Labour Sciences Research Grants for Comprehensive Research on Persons with Disabilities from the Japan Agency for Medical Research and Development (AMED) Grant Number 16dk0307029h0003 to MS.