A Role for MAIT Cells in Colorectal Cancer
Stuart P Berzins, Morgan E Wallace, George Kannourakis, Jason Kelly
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2020
MAIT cells are MR1-restricted T cells that are well-known for their anti-microbial properties, but they have recently been associated with different forms of cancer. Several studies have reported activated MAIT cells within the microenvironment of colorectal tumors, but there is conjecture about the nature of their response and whether they are contributing to anti-tumor immunity, or to the progression of the disease. We have reviewed the current state of knowledge about the role of MAIT cells in colorectal cancer, including their likely influence when activated and potential sources of stimulation in the tumor microenvironment. The prospects for MAIT cells being used in clinical settings as..View full abstract
SB supported by a Dorevitch Cancer Research Fellowship. JK was supported by a PhD scholarship from Lung Foundation Australia, and an Australian Government Research Training Program Fee-Offset Scholarship through Federation University Australia.