Journal article

Re-evaluating and recalibrating predictors of bacterial infection in children with cancer and febrile neutropenia

Gabrielle M Haeusler, Robert Phillips, Monica A Slavin, Franz E Babl, Richard De Abreu Lourenco, Francoise Mechinaud, Karin A Thursky, undefined Australian PICNICC study group and the PREDICT network

EClinicalMedicine | Lancet | Published : 2020

Abstract

Background: Numerous paediatric febrile neutropenia (FN) clinical decision rules (CDRs) have been derived. Validation studies show reduced performance in external settings. We evaluated the association between variables common across published FN CDRs and bacterial infection and recalibrated existing CDRs using these data. Methods: Prospective data from the Australian-PICNICC study which enrolled 858 FN episodes in children with cancer were used. Variables shown to be significant predictors of infection or adverse outcome in >1 CDR were analysed using multivariable logistic regression. Recalibration included re-evaluation of beta-coefficients (logistic model) or recursive-partition analysis ..

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Grants

Awarded by Medical Research Council


Awarded by Department of Health


Funding Acknowledgements

This study was funded by National Health and Medical Research Council (NHMRC) Project Grant (APP1104527). We gratefully acknowledge the support and endorsement of the Australian and New Zealand Children's Haematology/Oncology Group (ANZCHOG) and the Paediatric Research in Emergency Departments International Collaborative (PREDICT).