Journal article

Why Woody got the blues: The neurobiology of depression in Huntington's disease

Carolina Gubert, Thibault Renoir, Anthony J Hannan

Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

Huntington's disease (HD) is an extraordinary disorder that usually strikes when individuals are in the prime of their lives, as was the case for the influential 20th century musician Woody Guthrie. HD demonstrates the exceptionally fine line between life and death in such 'genetic diseases', as the only difference between those who suffer horribly and die slowly of this disease is often just a handful of extra tandem repeats (beyond the normal polymorphic range) in a genome that constitutes over 3 billion paired nucleotides of DNA. Furthermore, HD presents as a complex and heterogenous combination of psychiatric, cognitive and motor symptoms, so can appear as an unholy trinity of 'three dis..

View full abstract