Why Woody got the blues: The neurobiology of depression in Huntington's disease
Carolina Gubert, Thibault Renoir, Anthony J Hannan
Neurobiology of Disease | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020
Huntington's disease (HD) is an extraordinary disorder that usually strikes when individuals are in the prime of their lives, as was the case for the influential 20th century musician Woody Guthrie. HD demonstrates the exceptionally fine line between life and death in such 'genetic diseases', as the only difference between those who suffer horribly and die slowly of this disease is often just a handful of extra tandem repeats (beyond the normal polymorphic range) in a genome that constitutes over 3 billion paired nucleotides of DNA. Furthermore, HD presents as a complex and heterogenous combination of psychiatric, cognitive and motor symptoms, so can appear as an unholy trinity of 'three dis..View full abstract
CG is recipient of a University of Melbourne Early Career Researcher Award. TR is an NHMRC Dementia Fellow. AJH is an NHMRC Principal Research Fellow and is also supported by NHMRC Project Grants, an ARC Discovery Project and the DHB Foundation, Equity Trustees.