Preoperative opioid use and complications following total joint replacement: a protocol for a systematic review and meta-analysis.
Cade Shadbolt, Daniel Gould, Ximena Camacho, Josh Knight, Siddharth Rele, Sharmala Thuraisingam, Yuting Zhang, Michelle M Dowsey, Peter Fm Choong
BMJ Open | BMJ Journals | Published : 2020
INTRODUCTION: Mounting evidence now indicates that preoperative opioid use is associated with an array of complications following total joint replacement (TJR). However, evidence of these risks remains fragmented. A comprehensive and well-integrated understanding of this body of evidence is necessary to appropriately inform treatment decisions, the allocation of limited healthcare resources, and the direction of future clinical research. The proposed systematic review and meta-analysis aims to identify and synthesise the available evidence of an association between opioid use prior to TJR and postoperative complications, categorised by complication type. METHODS AND ANALYSIS: We will search ..View full abstract
Awarded by NHMRC Career Development Fellowship
Awarded by NHMRC
CS is supported by an Australian Government Research Training Program Scholarship. MCI is supported by a MidCareer Fellowship from The Hospital Research Foundation. MMD holds an NHMRC Career Development Fellowship (APP1122526) and University ofMelbourne Dame Kate Campbell Fellowship. PFMC holds an NHMRC Practitioner Fellowship (APP1154203).