Polyethylene Glycol Dosing for Constipation in Children Younger Than 24 Months: A Systematic Review
Helisa Rachel, Andrew F Griffith, Warwick J Teague, John M Hutson, Susan Gibb, Sharon Goldfeld, Misel Trajanovska, Sebastian K King
Journal of Pediatric Gastroenterology and Nutrition | LIPPINCOTT WILLIAMS & WILKINS | Published : 2020
OBJECTIVES: Evaluate safety and effectiveness of Polyethylene glycol (PEG) for chronic constipation in children aged younger than 24 months. Identify the optimum dose of PEG to manage chronic constipation in children aged younger than 24 months. METHODS: In this systematic review, Embase, Medline Ovid, Pubmed, and the Cochrane Library were searched between January 1, 2000 and February 1, 2019. Studies investigating functional constipation, in which patients younger than 24 months of age were treated with PEG, were considered as potentially eligible for review. Two authors screened the studies against inclusion/exclusion criteria. Study quality was assessed with the PEDro quality assessment, ..View full abstract
The authors would like to thank Poh Chua for her assistance with the systematic literature search; Krithika Sundaram and Anita J Horvath for their guidance during data synthesis; and The Royal Children's Hospital Foundation for their support of the project team.