Journal article

Challenges and Opportunities in the Pharmacological Treatment of Acute Venous Thromboembolism in Children

Carly George, Marzia Rahman, Paul Monagle

Pediatric Drugs | ADIS INT LTD | Published : 2020


Venous thromboembolism (VTE) is an important but historically under-recognized problem in pediatrics, with an incidence concentrated in hospitalized children. A number of specific VTE diseases with discrete triggers have been described, but the most common pediatric trigger is the presence of central venous access devices. VTE diseases, though heterogenous in etiology, are linked by the common therapeutic strategies shared by their management. Historically, the most commonly used drug therapies have been unfractionated heparin, low-molecular-weight heparins, and vitamin K antagonists, based on extrapolation from adult data rather than any specific pediatric trials. Although these widely used..

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