Journal article

Conduit arterial wave reflection promotes pressure transmission but impedes hydraulic energy transmission to the microvasculature

Avinash Kondiboyina, Joseph J Smolich, Michael MH Cheung, Berend E Westerhof, Jonathan P Mynard

AJP Heart and Circulatory Physiology | AMER PHYSIOLOGICAL SOC | Published : 2020

Abstract

Current thinking suggests that wave reflection in arteries limits pulse pressure and hydraulic energy (HE) transmission to the microvasculature and that this protective effect reduces with advancing age. However, according to transmission line theory, pressure transmission (Tp) and reflection (R) coefficients are proportional (Tp = 1 + R), implying that wave reflection would promote rather than limit pressure transmission. We hypothesized that increasing distal pulse pressure (PPd) with age is instead related to increased proximal pulse pressure (PPp) and its forward component and that these are modulated by arterial compliance. A one-dimensional model of a fractal arterial tree containing 2..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Funding Acknowledgements

J.P.M. was supported by a cofunded Career Development Fellowship from the National Health and Medical Research Council of Australia (APP1143510) and Future Leader Fellowship from the National Heart Foundation of Australia (101199). The Heart Research group at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program, RCH 1000, and Big W.