Journal article
BCG Vaccination in Humans Elicits Trained Immunity via the Hematopoietic Progenitor Compartment
B Cirovic, LCJ de Bree, L Groh, BA Blok, J Chan, WJFM van der Velden, MEJ Bremmers, R van Crevel, K Händler, S Picelli, J Schulte-Schrepping, K Klee, M Oosting, VACM Koeken, J van Ingen, Y Li, CS Benn, JL Schultze, LAB Joosten, N Curtis Show all
Cell Host and Microbe | CELL PRESS | Published : 2020
Abstract
Cirovic and de Bree et al. investigate the effects of BCG vaccination in humans and reveal the induction of a transcriptomic rewiring of human stem and progenitor cells toward the myeloid cell lineage, instructed by hepatic nuclear factors, resulting in epigenetic and functional changes within CD14+ peripheral monocytes.
Grants
Awarded by Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Funding Acknowledgements
This study was supported by an ERC advanced grant (#833247) and a Spinoza grant of the Netherlands Organization for Scientific Research (to M.G.N.). Additionally, this study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy - EXC2151 - 390873048 (to M.G.N., A.S., and J.L.S.), and an Emmy Noether research grant (SCHL2116/1 to A.S.). CVIVA is established with a grant from the Danish National Research Foundation (DNRF108). Additionally, this project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement no 733100 (to J.L.S.).