Roles of bone-derived hormones in type 2 diabetes and cardiovascular pathophysiology.
Xuzhu Lin, Danise-Ann Onda, Chieh-Hsin Yang, Joshua R Lewis, Itamar Levinger, Kim Loh
Mol Metab | Published : 2020
BACKGROUND: Emerging evidence demonstrates that bone is an endocrine organ capable of influencing multiple physiological and pathological processes through the secretion of hormones. Recent research suggests complex crosstalk between the bone and other metabolic and cardiovascular tissues. It was uncovered that three of these bone-derived hormones-osteocalcin, lipocalin 2, and sclerostin-are involved in the endocrine regulations of cardiometabolic health and play vital roles in the pathophysiological process of developing cardiometabolic syndromes such as type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation is one of the hallmarks of cardiometabolic diseases and a major..View full abstract
Awarded by National Heart Foundation Future Leader Fellowship
Awarded by National Health and Medical Research Council