Restricted Effect of Cerebral Microbleeds on Regional Magnetic Susceptibility
Amir Fazlollahi, Parnesh Raniga, Pierrick Bourgeat, Paul Yates, Ashley I Bush, Olivier Salvado, Scott Ayton
Journal of Alzheimer's Disease | IOS PRESS | Published : 2020
BACKGROUND: Cortical iron accumulation has been reported as a pathological feature of Alzheimer's disease (AD). The cause of cortical iron elevation in AD is unknown but may be contributed by hemosiderin deposits in cerebral microbleeds that frequently occur in this disease. OBJECTIVE: To investigate the impact of cerebral microbleeds (which are more frequent in AD) on the magnetic susceptibility of the surrounding brain tissue. METHODS: 32 MRI scans from the Australian Imaging, Biomarker and Lifestyle (AIBL) study were found to have cerebral microbleeds by manual assessment of susceptibility weighted images. Quantitative susceptibility mapping (QSM; an MRI technique that is sensitive to iro..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
This study was funded by the Cooperative Research Centre for Mental Health, Commonwealth Science and Industry Research Organization (CSIRO), National Health and Medical Research Council (NHMRC) Fellowships: GNT1103703 (A.I.B.) and GNT1100458 (S.A.), and NHMRC project grant: GNT1101533. The Florey Institute of Neuroscience and Mental Health acknowledges support from the Victorian Government, in particular, funding from the Operational Infrastructure Support Grant.