Journal article

Review: amino acid biosynthesis as a target for herbicide development

Cody J Hall, Emily RR Mackie, Anthony R Gendall, Matthew A Perugini, Tatiana P Soares da Costa

PEST MANAGEMENT SCIENCE | JOHN WILEY & SONS LTD | Published : 2020

Abstract

There are three amino acid biosynthesis pathways that are targeted by current herbicides, namely those leading to the production of aromatic amino acids, branched chain amino acids and glutamine. However, their efficacy is diminishing as a result of the increasing number of resistant weeds. Indeed, resistance to most classes of herbicides is on the rise, posing a significant threat to the utility of current herbicides to sustain effective weed management. This review provides an overview of potential herbicide targets within amino acid biosynthesis that remain unexploited commercially, and recent inhibitor discovery efforts. Despite contemporary approaches to herbicide discovery, such as che..

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University of Melbourne Researchers