Journal article
Iron Deficiency Is Associated with Reduced Levels of Plasmodium falciparum-specific Antibodies in African Children
CK Bundi, A Nalwoga, L Lubyayi, JM Muriuki, RM Mogire, H Opi, AJ Mentzer, CK Mugyenyi, J Mwacharo, EL Webb, P Bejon, TN Williams, JK Gikunju, JG Beeson, AM Elliott, FM Ndungu, SH Atkinson
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021
DOI: 10.1093/cid/ciaa728
Open access
Abstract
Background: Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria. Methods: The study included 1794 Kenyan and Ugandan children aged 0-7 years. We measured biomarkers of iron and inflammation, and antibodies to P. falciparum antigens including apical merozoite antigen 1 (anti-AMA-1) and merozoite surface antigen 1 (anti-MSP-1) in cross-sectional and longitudinal studies. Results: The overall prevalence of ID was 31%. ID was associated with lower anti-AMA-1 and an..
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Awarded by Wellcome Trust
Funding Acknowledgements
This work was supported by Wellcome (grant numbers 110255 to S. H. A., 202800 to T. N. W., 10628 to A. J. M., and grant numbers 064693, 079110, 095778 to A. M. E.). Wellcome provides a core award to the KEMRI-Wellcome Trust Research Programme (grant number 203077). A. J. M. was also supported by an Oxford University Clinical Academic School Transitional Fellowship. J. G. B. was supported by a Senior Research Fellowship of the National Health and Medical Research Council of Australia (grant number 1077636). C. K. B., R. M. M., and J. M. M. were supported through the DELTAS Africa Initiative (DEL-15-003). L. L. is supported by a PhD fellowship through the DELTAS Africa Initiative Sub-Saharan Africa Consortium for Advanced Biostatistics Training (SSACAB, grant number 107754). The DELTAS Africa Initiative is an independent funding scheme of the African Academy of Sciences's Alliance for Accelerating Excellence in Science in Africa (AESA) and supported by the New Partnership for Africa's Development Planning and Coordinating Agency (NEPAD Agency) with funding from Wellcome (grant numbers 107769, 107743) and the UK government. The Ugandan cohort was conducted at the MRC/UVRI and LSHTM Uganda Research Unit which is jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 Program supported by the European Union.