Iron deficiency is associated with reduced levels of Plasmodium falciparum-specific antibodies in African children.
Caroline K Bundi, Angela Nalwoga, Lawrence Lubyayi, John Muthii Muriuki, Reagan M Mogire, Herbert Opi, Alexander J Mentzer, Cleopatra K Mugyenyi, Jedida Mwacharo, Emily L Webb, Philip Bejon, Thomas N Williams, Joseph K Gikunju, James G Beeson, Alison M Elliott, Francis M Ndungu, Sarah H Atkinson
Clinical Infectious Diseases | Published : 2020
BACKGROUND: Iron deficiency (ID) and malaria are common causes of ill-health and disability among children living in sub-Saharan Africa. Although iron is critical for the acquisition of humoral immunity, little is known about the effects of ID on antibody responses to Plasmodium falciparum malaria. METHODS: The study included 1,794 Kenyan and Ugandan children aged 0-7 years. We measured biomarkers of iron and inflammation, and antibodies to P falciparum antigens including apical merozoite antigen 1 (anti-AMA-1) and merozoite surface antigen 1 (anti-MSP-1) in cross-sectional and longitudinal studies. RESULTS: The overall prevalence of ID was 31%. ID was associated with lower anti-AMA-1 and an..View full abstract