Journal article

Lung and Eye Disease Develop Concurrently in Supplemental Oxygen-Exposed Neonatal Mice

Lakshanie C Wickramasinghe, Maverick Lau, Devy Deliyanti, Timothy A Gottschalk, Peter van Wijngaarden, Dean Talia, Chad Johnson, Jennifer L Wilkinson-Berka, Evelyn Tsantikos, Margaret L Hibbs

The American Journal of Pathology | ELSEVIER SCIENCE INC | Published : 2020

Abstract

Bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) are two debilitating disorders that develop in preterm infants exposed to supplemental oxygen to prevent respiratory failure. Both can lead to lifelong disabilities, such as chronic obstructive pulmonary disease and vision loss. Due to the lack of a standard experimental model of coincident disease, the underlying associations between BPD and ROP are not well characterized. To address this gap, we used the robust mouse model of oxygen-induced retinopathy exposing C57BL/6 mice to 75% oxygen from postnatal day 7 to 12. The cardinal features of ROP were replicated by this strategy, and the lungs of the same mice were simultan..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

Supported by National Health and Medical Research Council grants APP1147267 (M.L.H.) and APP1141208 (E.T. and M.L.H.) and an Australia Government Research Training Program scholarship administered by Monash University (L.C.W.).