Journal article

Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults

Matthew R Scott, Olivia L Hampton, Rachel F Buckley, Jasmeer P Chhatwal, Bernard J Hanseeuw, Heidi IL Jacobs, Michael J Properzi, Justin S Sanchez, Keith A Johnson, Reisa A Sperling, Aaron P Schultz



Neurofibrillary tau tangles are a hallmark pathology of Alzheimer's disease (AD) and are more closely associated with AD-related cortical atrophy and symptom severity than amyloid-beta (Aβ). However, studies regarding the effect of tau on longitudinal cortical thinning, particularly in healthy aging and preclinical AD, have been limited in number due to the relatively recent introduction of in vivo PET tracers for imaging tau pathology. Here, we investigate [18F]-flortaucipir (FTP, a marker of paired helical filament tau) PET as a predictor of atrophy in healthy aging and preclinical AD. We examine longitudinal structural MRI brain imaging data, retrospectively and prospectively relative to ..

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Awarded by National Institutes of Health

Awarded by Center for Functional Neuroimaging Technologies

Awarded by NIH

Funding Acknowledgements

We would like to acknowledge the participants of the Harvard Aging Brain Study for their dedication. This work was supported with funding from National Institutes of Health grants via R01AG027435 and for the Harvard Aging Brain Study (P01AG036694) and R01AG046396 (Dr. Johnson). This research was carried out at the Athinoula A. Martinos Center for Biomedical Imaging at the Massachusetts General Hospital, using resources provided by the Center for Functional Neuroimaging Technologies (P41EB015896), a P41 Biotechnology Resource Grant supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health. This work also involved the use of instrumentation supported by the NIH Shared Instrumentation Grant Program and/or High-End Instrumentation Grant Program; specifically, S10RR021110, S10RR023401, S10RR019307, S10RR019254, and S10RR023043.