Transient childhood wheeze is associated with less atopy in adolescence

CJ Lodge; AJ Lowe; MJ Abramson; C Svanes; SG Zaloumis; PS Thomas; SC Dharmage

Journal article

Transient childhood wheeze is associated with less atopy in adolescence

CJ Lodge, AJ Lowe, MJ Abramson, C Svanes, SG Zaloumis, PS Thomas, SC Dharmage

Pediatric Allergy and Immunology | WILEY | Published : 2020

DOI: 10.1111/pai.13304

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Abstract

Background: The relationships between childhood wheeze phenotypes and subsequent allergic conditions other than asthma, including hay fever, eczema and sensitization, have not been widely reported. We aimed to investigate this relationship up to late adolescence. Methods: Using five childhood wheeze phenotypes defined from 620 children in a high-atopy risk birth cohort (Melbourne Atopy Cohort Study), we investigated their relationships with sensitization, eczema, hay fever and fractional exhaled nitric oxide (FeNO) at ages 12 and/or 18 years using logistic and linear regression models. Results: ‘Early Persistent wheeze’ was associated with the increased risk of eczema (odds ratio: 3.69; 95% ..

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University of Melbourne Researchers

Caroline Lodge Author

Adrian Lowe Author

Shyamali Dharmage Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The first 6 years of the Melbourne Atopy Cohort Study was funded by Nestec Ltd, a subsidiary of Nestle Australia. The 12year follow-up was funded by a project grant from the Asthma Foundation of Victoria. The National Health and Medical Research Council of Australia funded the 18-year follow-up (APP454856). None of these funding bodies have influenced the interpretation or publication of study findings.