Journal article

Autism-associated synaptic mutations impact the gut-brain axis in mice

Chalystha Yie Qin Lee, Ashley E Franks, Elisa L Hill-Yardin

Brain Behavior and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2020

Abstract

Interactions between the gut microbiome and the brain affect mood and behaviour in health and disease. Using preclinical animal models, recent discoveries begin to explain how bacteria in the gut influence our mood as well as highlighting new findings relevant to autism. Autism-associated gene mutations known to alter synapse function in the CNS also affect inflammatory response and modify the enteric nervous system resulting in abnormal gastrointestinal motility and structure. Strikingly, these mutations additionally affect the gut microbiome in mice. This review describes the changes in gut physiology and microbiota in mouse models of autism with modified synapse function. The rationale fo..

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University of Melbourne Researchers

Grants

Awarded by ARC Future Fellowship


Funding Acknowledgements

CYQL, AEF and ELH-Y wrote the manuscript. All authors approved the manuscript for submission. ELH-Y was supported by an ARC Future Fellowship (FT160100126) and an RMIT Vice Chancellor's Senior Research Fellowship. CYQL received the RMIT Research Stipend Scholarship (RRSS).