Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data.
CA Vollgraff Heidweiller-Schreurs, IR van Osch, MW Heymans, W Ganzevoort, LJ Schoonmade, CJ Bax, Bwj Mol, Cjm de Groot, Pmm Bossuyt, MA de Boer, undefined CPR IPD Study Group
BJOG: an International Journal of Obstetrics and Gynaecology | Published : 2021
OBJECTIVE: To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone - standard of practice - for adverse perinatal outcome in singleton pregnancies. DESIGN AND SETTING: Meta-analysis based on individual participant data (IPD). POPULATION OR SAMPLE: Ten centres provided 17 data sets for 21 661 participants, 18 731 of which could be included. Sample sizes per data set ranged from 207 to 9215 individuals. Patient populations varied from uncomplicated to complicated pregnancies. METHODS: In a collaborative, pooled analysis, we compared the prognostic value of combining CPR with UA PI, versus UA PI only and CPR only, with a on..View full abstract