Neuronal Reprogramming for Tissue Repair and Neuroregeneration
Roxanne Hsiang-Chi Liou, Thomas L Edwards, Keith R Martin, Raymond Ching-Bong Wong
International Journal of Molecular Sciences | MDPI | Published : 2020
Stem cell and cell reprogramming technology represent a rapidly growing field in regenerative medicine. A number of novel neural reprogramming methods have been established, using pluripotent stem cells (PSCs) or direct reprogramming, to efficiently derive specific neuronal cell types for therapeutic applications. Both in vitro and in vivo cellular reprogramming provide diverse therapeutic pathways for modeling neurological diseases and injury repair. In particular, the retina has emerged as a promising target for clinical application of regenerative medicine. Herein, we review the potential of neuronal reprogramming to develop regenerative strategy, with a particular focus on treating retin..View full abstract
This research was funded by the National Health and Medical Research Council (R.C.-B.W.), the University of Melbourne (De Brettville Trust, R.C.-B.W.; Melbourne Research Scholarship, R.H.-C.L.), Centre for Eye Research Australia (R.C.-B.W.), and Fight for Sight UK (K.R.M.). The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government.