Modeling Thrombin Generation in Plasma under Diffusion and Flow.
Christian JC Biscombe, Steven K Dower, Ineke L Muir, Dalton JE Harvie
Biophysical Journal | Biophysical Society | Published : 2020
We investigate the capacity of published numerical models of thrombin generation to reproduce experimentally observed threshold behavior under conditions in which diffusion and/or flow are important. Computational fluid dynamics simulations incorporating species diffusion, fluid flow, and biochemical reactions are compared with published data for thrombin generation in vitro in 1) quiescent plasma exposed to patches of tissue factor and 2) plasma perfused through a capillary coated with tissue factor. Clot time is correctly predicted in individual cases, and some models qualitatively replicate thrombin generation thresholds across a series of tissue factor patch sizes or wall shear rates. Nu..View full abstract
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Awarded by Australian Research Council
This research was supported by the Australian Government through the Australian Research Council's Linkage Project funding scheme (project LP160100786). Some computations were completed on the Spartan High Performance Computing system (96) operated by Research Computing Services at The University of Melbourne.