Journal article

Appraising causal relationships of dietary, nutritional and physical-activity exposures with overall and aggressive prostate cancer: two-sample Mendelian-randomization study based on 79148 prostate-cancer cases and 61106 controls

Nabila Kazmi, Philip Haycock, Konstantinos Tsilidis, Brigid M Lynch, Therese Truong, Richard M Martin, Sarah J Lewis

International Journal of Epidemiology | OXFORD UNIV PRESS | Published : 2020

Abstract

BACKGROUND: Prostate cancer is the second most common male cancer worldwide, but there is substantial geographical variation, suggesting a potential role for modifiable risk factors in prostate carcinogenesis. METHODS: We identified previously reported prostate cancer risk factors from the World Cancer Research Fund (WCRF)'s systematic appraisal of the global evidence (2018). We assessed whether each identified risk factor was causally associated with risk of overall (79 148 cases and 61 106 controls) or aggressive (15 167 cases and 58 308 controls) prostate cancer using Mendelian randomization (MR) based on genome-wide association-study summary statistics from the PRACTICAL and GAME-ON/ELLI..

View full abstract

Grants

Awarded by World Cancer Research Fund (WCRF UK), World Cancer Research Fund International grant programme


Awarded by Cancer Research UK programme


Awarded by CRUK Population Research Postdoctoral Fellowship


Awarded by Mid-Career Research Fellowship from the Victorian Cancer Agency


Funding Acknowledgements

Funding for grant 2015/1421 was obtained from World Cancer Research Fund (WCRF UK), as part of the World Cancer Research Fund International grant programme, a Cancer Research UK programme grant (C18281/A19169) and the National Institute for Health Research (NIHR) Bristol Biomedical Research Centre. Dr Haycock is supported by CRUK Population Research Postdoctoral Fellowship (C52724/A20138). Dr Lynch was supported by a Mid-Career Research Fellowship from the Victorian Cancer Agency (MCRF18005). The views expressed are those of the author(s) and not necessarily those of the funders.