Journal article

Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice

Yanhong Ni, Tami Yap, Natasha Silke, John Silke, Michael McCullough, Antonio Celentano, Lorraine A O'Reilly

ORAL DISEASES | WILEY | Published : 2021

Abstract

This article is protected by copyright. All rights reserved. Oral squamous cell carcinoma (OSCC) is a major subcategory of head and neck squamous cell carcinomas (HNSCC) and is currently the 6th highest cause of cancer mortality world-wide (Bray et al., 2018; Siegel, Miller, & Jemal, 2019). Despite current treatments such as surgery with adjunctive radiation and chemotherapy, the 5-year survival has remained at 50% for decades (Kumar, Nanavati, Modi, & Dobariya, 2016; Rivera, 2015). Most human solid cancers are believed to be driven by chronic inflammation that instigates nascent tumour proliferation (dysplasia), transformation and metastasis while conversely suppressing anti-tumour immune r..

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