Journal article

Loss of NF-kB1 and c-Rel accelerates oral carcinogenesis in mice

Yanhong Ni, Tami Yap, Natasha Silke, John Silke, Michael McCullough, Antonio Celentano, Lorraine A O'Reilly

ORAL DISEASES | WILEY | Published : 2021


This article is protected by copyright. All rights reserved. Oral squamous cell carcinoma (OSCC) is a major subcategory of head and neck squamous cell carcinomas (HNSCC) and is currently the 6th highest cause of cancer mortality world-wide (Bray et al., 2018; Siegel, Miller, & Jemal, 2019). Despite current treatments such as surgery with adjunctive radiation and chemotherapy, the 5-year survival has remained at 50% for decades (Kumar, Nanavati, Modi, & Dobariya, 2016; Rivera, 2015). Most human solid cancers are believed to be driven by chronic inflammation that instigates nascent tumour proliferation (dysplasia), transformation and metastasis while conversely suppressing anti-tumour immune r..

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Awarded by Cancer Council New South Wales project

Awarded by NHMRC

Awarded by NHMRC fellowship

Awarded by Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS

Awarded by Cancer Council Victoria Grant-in-Aid project