Characterising the effects of per- and polyfluoroalkyl substances (PFASs) on health and disease: An opportunity for exposomics?

Abstract

© 2020 Elsevier B.V. Human exposure to mixtures of perfluoroalkyl and polyfluoroalkyl substances (PFASs) constitutes an important issue in environmental epidemiology and the adoption of more holistic approaches to reduce the uncertainties associated with their human health effects is a critical research need. The ‘exposome’, defined as the totality of environmental (i.e. nongenetic) exposures from conception onward represents a new path towards understanding environmental determinants of human disease by assessing the multitude of exposures and risk of adverse health outcomes that occur over a lifetime. Here, we review the limitations of traditional approaches to PFAS health assessments and ..