Journal article
Oral Delivery of β-Lactoglobulin-Nanosphere-Encapsulated Resveratrol Alleviates Inflammation in Winnie Mice with Spontaneous Ulcerative Colitis
N Pujara, KY Wong, Z Qu, R Wang, M Moniruzzaman, P Rewatkar, T Kumeria, BP Ross, M McGuckin, A Popat
Molecular Pharmaceutics | AMER CHEMICAL SOC | Published : 2021
Abstract
Resveratrol (RES) is a nutraceutical with promising anti-inflammatory properties for the treatment of inflammatory bowel diseases (IBD). However, the clinical effectiveness of resveratrol as an oral anti-inflammatory agent is hindered by its extremely poor solubility and poor stability. In this study, we encapsulated resveratrol in β-lactoglobulin (BLG) nanospheres and systematically analyzed their formulation parameters in vitro followed by a thorough in vivo anti-inflammatory testing in a highly specialized spontaneous murine UC model (Winnie mice model). Complexation of resveratrol with BLG increased the aqueous solubility of resveratrol by ≈1.7 times with 10% w/w loading. Additionally, t..
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Awarded by University of Queensland
Funding Acknowledgements
Authors are thankful for research maintenance funds provided by the School of Pharmacy, The University of Queensland, and funding provided by the Mater Medical Research Institute. A.P. and T.K. are thankful to the National Health and Medical Research Council of Australia for Career Development (GNT1146627) and Early Career Fellowship (GNT1143296), respectively. Authors are also thankful to the Center of Microscopy and Microanalysis (CMM) at UQ and TRI for providing facilities.