Journal article

Improvement in inner retinal function in glaucoma in response to nicotinamide (Vitamin B3) supplementation: a crossover randomized clinical trial

Flora Hui, Jessica Tang, Pete Williams, Myra McGuinness, Xavier Hadoux, Robert James Casson, Michael Coote, Ian Trounce, Keith R Martin, Peter van Wijngaarden, Jonathan Guy Crowston

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2020

Abstract

Importance: Retinal ganglion cells endure significant metabolic stress with ageing and glaucoma-related stressors. Injured cells require increased energy for repair but maintain capacity to recover function despite periods of functional loss. Nicotinamide, a precursor of redox co-factor and metabolite, NAD + , is low in serum of patients with primary open-angle glaucoma and its supplementation provides robust protection of retinal ganglion cells by targeting mitochondrial health in glaucoma models. However, the potential of nicotinamide to improve retinal ganglion cell function in humans with glaucoma is yet unknown. Objective: To determine whether nicotinamide supplementation taken in conju..

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Grants

Awarded by JBF Grant


Funding Acknowledgements

Support JBF Grant number 4354 -2017, ORIA Grant New Investigator