The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

X Zhang; L Yang; P Szeto; GK Abali; Y Zhang; A Kulkarni; K Amarasinghe; J Li; IA Vergara; R Molania; AT Papenfuss; C McLean; M Shackleton; KF Harvey

Journal article

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

X Zhang, L Yang, P Szeto, GK Abali, Y Zhang, A Kulkarni, K Amarasinghe, J Li, IA Vergara, R Molania, AT Papenfuss, C McLean, M Shackleton, KF Harvey

Oncogene | SPRINGERNATURE | Published : 2020

DOI: 10.1038/s41388-020-1362-9

Abstract

Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younger people. Compared with most other skin cancers, a feature of melanoma is its high metastatic capacity, although the mechanisms that confer this are not well understood. The Hippo pathway is a key regulator of organ growth and cell fate that is deregulated in many cancers. To analyse the Hippo pathway in cutaneous melanoma, we generated a transcriptional signature of melanoma cells that overexpressed YAP, the key downstream Hippo pathway oncoprotein. YAP-mediated transcriptional activity varied in melanoma cell lines but did not cluster with known genetic drivers ..

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University of Melbourne Researchers

Xiaomeng Zhang Author

Jason Li Author

Ramyar Molania Author

Tony Papenfuss Author

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Grants

Awarded by State Government of Victoria

Funding Acknowledgements

We thank the following Peter MacCallum Cancer Centre core facilities: Molecular Genomics, Bioinformatics, Flow Cytometry and the Centre for Advanced Histology and Microscopy, which were in part supported by the Australian Cancer Research Foundation. KFH was supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1078220). MS was supported by Pfizer Australia, NHMRC, veski, and VCA Fellowships. This research was supported by grants from the Cancer Council of Victoria (APP1080255) and NHMRC (APP1145166), and by the Peter MacCallum Cancer Foundation. ATP was supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1116955) and by the Lorenzo and Pamela Galli Charitable Trust. The research benefitted by support from the Victorian State Government Operational Infrastructure Support and Australian Government NHMRC Independent Research Institute Infrastructure Support. LY was supported by the China Scholarship Council. AK was supported by an Australian Government Research Training Programme Scholarship and a Rosie Lew Peter MacCallum Cancer Foundation Postgraduate Award.